O-304 (ATX-304)

Metabolic, Muscle-Sparing & Performance Support*

$349.00

Burn Fat
Preserve Muscle
Train Longer

80 in stock

Size/Volume

60 capsules

Burns Fat Without Cutting Calories – Activates AMPK and mildly uncouples mitochondria to raise energy expenditure, so fuel is burned rather than stored — even when food intake stays the same.
Preserves Lean Muscle – In preclinical studies, weight lost on ATX-304 came almost entirely from fat, with lean mass spared — a striking contrast to typical GLP-1 weight loss.
Works Like Exercise – Drives insulin-independent glucose uptake into muscle, the same “metabolic back door” your body opens during a workout.
Supports Healthy Blood Sugar – Backed by human Phase 2a data showing improved fasting glucose and insulin sensitivity in type 2 diabetics.
Fuels Endurance & Circulation – AMPK-driven mitochondrial and vascular adaptations associated with better stamina, blood flow, and cardiac efficiency.

ATX-304 (also known as O-304) is an orally available small-molecule AMPK activator — AMPK being the master “fuel gauge” enzyme your cells switch on during exercise and fasting. Rather than forcing the switch, ATX-304 blocks the phosphatase (PP2C) that normally turns AMPK off, so your naturally elevated AMPK activity simply lasts longer — without the cell ever experiencing an energy crisis. Layered on top, it acts as a mild mitochondrial uncoupler, nudging cells to burn more fuel to produce the same energy. The combined effect — pull fuel into muscle, then burn it — mimics the metabolic signature of a workout: fat is mobilized and oxidized while lean tissue is fed and preserved.

Ideal for individuals looking to:

Lose fat without sacrificing hard-earned muscle
Protect lean mass on or after a GLP-1
Gain an “exercise-mimetic” metabolic edge
Support healthy blood sugar, endurance, and longevity

Take 1 capsule (200 mg) once or twice daily with food, or as directed by your healthcare provider. Users typically run ATX-304 in 8–12 week cycles. Best paired with a balanced diet and regular physical activity.

Exercise, distilled into a capsule.*

ATX-304 (O-304) is one of the most intriguing metabolic compounds in early-clinical development — a small molecule that switches on AMPK, the same cellular energy sensor exercise activates. It has been described as a compound that works like exercise, delivering a metabolic one-two punch: it pulls fuel into your cells, then burns it. The outcome is a clean, exercise-like phenotype — fat loss, preserved muscle, steadier blood sugar, and better endurance — without stimulants, injections, or appetite suppression.

Fat loss that spares your muscle.

What sets ATX-304 apart is its body-composition profile. In head-to-head preclinical studies, semaglutide-treated animals lost both fat and lean mass, while ATX-304-treated animals lost fat only — and when added to a GLP-1, it protected the lean tissue that would otherwise be lost. Because ATX-304 drives glucose directly into muscle to be used as fuel instead of suppressing appetite, the body has no reason to break down muscle for energy. In these studies animals even ate more while continuing to lose body fat.

Supplement Facts

Serving Size: 1 Capsule
Servings Per Container: 60 Capsules

Amount Per Serving	Amount	% DV
ATX-304 (O-304, pan-AMPK activator · CAS 1261289-04-6)	200 mg	**

** Daily Value not established.

Other Ingredients: Microcrystalline Cellulose, Magnesium Stearate, Hydroxypropyl Methylcellulose.

Suggested Use: Take 1 capsule, 1–2 times per day with food. For higher dosages please consult your health care provider.

Warning: Do not exceed recommended serving. Pregnant or nursing women, children under 18, and individuals with known medical conditions should consult their physician prior to taking. Keep out of reach of children. Do not use if safety seal is damaged or missing. Store in a cool, dry place.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Clinical Research & References

ATX-304 (also published as O-304) has been studied across at least four independent laboratories over nearly a decade. Preclinical work shows it activates AMPK and mildly uncouples mitochondria — increasing energy expenditure, driving insulin-independent glucose uptake into muscle, reducing fat mass while sparing lean tissue, lowering liver fat and cholesterol, and improving endurance and cardiac function. The single published human study — a Phase 2a proof-of-concept in type 2 diabetics on metformin — reported reduced fasting glucose, improved insulin sensitivity (HOMA-IR), lower blood pressure, and improved microvascular perfusion. Most body-composition and muscle findings to date are from animal models, and ATX-304 remains an investigational compound that has not been approved by the FDA or any regulatory agency. Review current literature and consult a qualified health professional before use.